Howard Hughes and Johnny Depp

What self-respecting Hollywood superstar would turn down the chance to be a germophobic recluse. Quite a few probably, but not Johnny Depp who's often proved himself ready to take a few risks with his roles. Hughes was a handsome playboy millionaire at 18, became a famous pilot and went out with Jean Harlow and Katharine Hepburn. Then came a plane crash and the descent into madness. Probably not a barrel of laughs, but fascinating nonetheless