The second coming of Doogie Howser M.D. has been one of the biggest joys of the past couple of years, with Harris putting his fresh-faced past behind him to find success as womanising Barney on the excellent sitcom, How I Met Your Mother. And Harris has used that success as a springboard to show off his many talents, including singing on Joss Whedon's Dr. Horrible's Sing-A-Long Blog, and outshining the cast of SNL on his recent hosting stint. Movie-wise, it's pretty much all about his turn as a stiff Nazi-esque army officer in Starship Troopers, and his raucous cameos as a heightened, boozing, drug-taking, ladykilling version of himself in the Harold & Kumar movies. Given that he's openly gay in real life, it's a very heightened version.

PICTURED Neil Patrick Harris